TAVOELITE

Current medical therapy is not without problems. Commonly used small molecule and antibody drugs both have multiple limitations.

There are several limitations of small molecule drugs:

• Small surface area exposure can limit binding affinity and specificity

• Poor modulation of protein-protein Interactions; Most designs cannot incorporate avidity or allosteric modulation

• Need for optimizing ADME

Meanwhile, there are also multiple limitations of antibody biologics as well:

• Biophysical properties prevent cell penetration and limit tissue penetration

• Many uncertainties in the drug product CMC and immunogenicity

• Manufacturing process complexity and high cost

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To respond to this unmet medical need, Tavotek has created TavoELITE, a novel platform that goes after intracellular targets for the treatment of cancer and other diseases.

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Features​

• Enhanced target cell-specific internalization​

• Efficient endosomal escape for intracellular target​

• Intracellular target intervention by protein-protein interaction (modulation, inhibition or degradation) and/or through RNA modulation (silencing or delivering) ​

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Building Blocks​

• Novel molecular constructs that enhance target cell-specific internalization (e.g., VHO and VHO-Fc)​

• CPP, EDD, circular RNA, etc. that enable efficient endosomal escape​

• Utilizing enhanced Fc function or by conjugating small molecule engager to enable ubiquitin protease-mediated degradation ​

• Fab, scFv, peptide, or small molecule that specifically interact with the intracellular protein target ​

• Shuttled gene therapy components